Bad News for -Cell Apoptosis

Bad News for β-Cell Apoptosis

A lthough necrosis also plays a role, -cell death by apoptosis precipitates type 1 diabetes and also contributes to both type 2 diabetes and islet graft failure after transplantation (1). It is therefore surprising that apoptotic pathways, so well explored in other cell types, have barely been characterized in -cells. A new study in Diabetes now adds to a growing body of work that addresses how...

Bad News for Chordal Partitions

Reed and Seymour [1998] asked whether every graph has a partition into induced connected subgraphs such that each part is bipartite and the quotient graph is chordal. If true, this would have significant ramifications for Hadwiger’s Conjecture. We prove that the answer is ‘no’. In fact, we show that the answer is still ‘no’ for several relaxations of the question.

NK cell exhaustion: bad news for chronic disease?

Natural killer (NK) cells are generally considered as the effector arm of nonspecific innate immunity, providing rapid recognition and lysis of virus-infected and tumor cells, but can also play significant regulatory roles in pregnancy, cooperate with T and B cell responses, and even exhibit independent adaptive memory. However, much like other lymphocyte populations, recent burgeoning evidence...

hiv/aids good news and bad news

Breaking bad news.